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KMID : 0360319930250020236
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Journal of Korean Cancer Research Association
1993 Volume.25 No. 2 p.236 ~ p.246
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Efficacy of Recombinant Human Granulocyte Colony-Stimulating Factor(Neutrogin) for Chemotherapy Induced Neutropenia in Patients with Advanced Lung Carcinoma
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유내춘
김주항/이이형/김세규/김성규/이원영/차봉수/최진혁/임호영
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Abstract
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Efficacy of recombinant human G-CSF(granulocyte colony-stimulating factor: Neutrogin(r)) was evaluated in 30 advanced lung carcinoma patients at Severance Hospital and Yonsei Cancer Center during the period of August, 1992 to January, 1993. Every
patient received same chemotherapy regimen at least 2 courses. Any patient who has the serious medical illness other than lung cancer or hypersensitivity to G-CSF was excluded. The first chemotherapy course without G-CSF was a control period for
evaluation of the degree of neutropenia and the second course with the G-CSF wsa evaluation period of G-CSF efficacy on neutropenia. G-CSF was administered subcutaneously with the dose of 2μg/kg/day for 14 days. The efficacy of G-CSF was
evaluated
according to the criteria of Japan Cancer Treatment Society.
@ES The following results were obtained.
@EN 1) Total number of enrolled patients were 30; twelve(40.0%) with the small cell lung cancer and eighteen(60.0%) with the non-small cell lung cancer. The chemotherapeutic regimens were EAP, VIP, MIF and CAV.
2) Mean nadir of WBC counts during the control period and evaluation period were 1334.0+689.2/㎣, respectively(P<0.001).
3) Mean nadir of neutrophil counts during the control period and evaluation period were 311.3±263.2/㎣ and 1915.1±1989.0/㎣, respectively(P<0.001).
4) Mean duration of WBC counts less than 1000/㎣ were 1.7±2.67 days in the control period and 0.6±1.89 days in the evaluation period(P<0.02).
5) Mean duration of neutrophil counts less than 500/㎣ were 4.9±3.01 days in the control period and 0.7±1.69 days in the evaluation period(P<0.001).
6) The recovery time of WBC from nadir to≥30003 was 7.3±4.4 days in the control period and 1.9±1.94 days in the evaluation period(P<0.001).
7) The recovery time of neutrophil from nadir to≥1500/㎣ was 6.7±3,73 days in the control period and 1.5±1.57 days in the evaluation period(P<0.001).
8) Side effects of G-CSF were mild back pain observed in four patients(13.3%), mild fever and general weakness in one(3.3%) respectively. Slight elevation of transaminase observed in one case(3.3%) which was normalized before next chemotherapy
cycle
without specific treatment.
In conclusion, G-CSF was very useful in 23 case(76.6%) and useful in 7 case(23.4%) for chemotherapy induced neutropenia in the lung cancer patients. The side effects of G-CSF were acceptable.
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KEYWORD
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